![]() ![]() In essence, the RPE contributes to the blood-retina barrier. The basal area (which is adjacent to Bruch’s membrane) has many infoldings. They have microvilli on their apical portions that engage with the outer segment of photoreceptor cells. The human eye consists of approximately 4-6 million RPE cells per eye. The retinal pigment epithelium (RPE) is a layer of cuboidal epithelial cells placed between choriocapillaris and the outer segment of the photoreceptor cells. Pheomelanin is a xanthous pigment that is synthetized when glutathione or cysteine is included in the oxidation phase of levodopa. ![]() ![]() Uveal melanocytes consist both of eumelanin and pheomelanin, but pheomelanin is frequently present more than eumelanin. In the uveal layer, the features of melanin pigment differ with the iris color. The turnover of retinal melanosomes is not fully elucidated. Consequently, melanin biosynthesis is null or tiny in adult human RPE cells. The melanin amount in the RPE reduces importantly in aged eyes. There are two types of eumelanin, which are brown and black, synthetized from levodopa or tyrosine. Melanin in the retinal pigment epithelium is mostly eumelanin. The retinal pigment epithelium is naturally intensely pigmented. ![]()
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